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Welcome to the Sternberg Lab! 

Our laboratory is interested in the systems biology of nematodes.  We seek to understand how the properties of an organism are encoded in its genome.

Lab News

February, 2019. Mengyi Cao was awarded a Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctroal Fellowship F32.

March, 2019. We were awarded 1.7 million from the Eunice Kennedy Shriver Institute of Child Health & Human Development to study the role of acetylcholine in cell migration, a collaboration with Dr. Mihoko Kato of Pomona College.

May 13, 2019.  Wen Chen defended her thesis "Proteomic profiling and functional characterization of C. elegans-expressed secreted proteins".

May 29, 2019.  Jonathan Liu defended his thesis "Engineering and application of cGAL, a GAL4 bipartite expression system for Caenorhabditis elegans."

Strain/Reagent Requests

To request a published strain or reagent, please email Barbara Perry.  For unpublished strains or reagents, please email Paul Sternberg.

New Publications

1. Lee RYN, Howe KL, Harris TW, Arnaboldi V, Cain S, Chan J, Chen WJ, Davis P, Gao S, Grove C, Kishore R, Muller HM, Nakamura C, Nuin P, Paulini M, Raciti D, Rodgers F, Russell M, Schindelman G, Tuli MA, Van Auken K, Wang Q, Williams G, Wright A, Yook K, Berriman M, Kersey P, Schedl T, Stein L, Sternberg PW. WormBase 2017: molting into a new stage. Nucleic Acids Res. 2018 Jan 4;46(D1):D869-D874. doi: 10.1093/nar/gkx998. PubMed PMID: 29069413; PubMed Central PMCID: PMC5753391.

2. Schwartz, H.T., & Sternberg, P.W. A Toolkit of Engineered Recombinational Balancers in C. elegans. Trends Genet. 2018 doi: 10.1016/j.tig.2018.01.009.

3. Angeles-Albores D, Puckett Robinson C, Williams BA, Wold BJ, Sternberg PW. Reconstructing a metazoan genetic pathway with transcriptome-wide epistasis measurements. Proc Natl Acad Sci U S A. 2018 Mar 12. pii: 201712387. doi: 10.1073/pnas.1712387115. [Epub ahead of print] PubMed PMID: 29531064.

4. Müller HM, Van Auken KM, Li Y, Sternberg PW. Textpresso Central: a customizable platform for searching, text mining, viewing, and curating biomedical literature. BMC Bioinformatics. 2018 Mar 9;19(1):94. doi: 10.1186/s12859-018-2103-8. PubMed PMID: 29523070.

5. Artyukhin AB, Zhang YK, Akagi AE, Panda O, Sternberg PW, Schroeder FC. Metabolomic "Dark Matter" Dependent on Peroxisomal β-Oxidation in Caenorhabditis elegans. J Am Chem Soc. 2018 Feb 28;140(8):2841-2852. doi: 10.1021/jacs.7b11811. Epub 2018 Feb 16. PubMed PMID: 29401383.

6. Wang H, Liu J, Yuet KP, Hill AJ, Sternberg PW. (2018) Split cGAL, an intersectional strategy using a split intein for refined spatiotemporal transgene control in C. elegans. PNAS. [Epub ahead of print]

7.  Angeles-Albores D, Sternberg PW. Using Transcriptones as Mutant Phenotypes Reveals Functional Regions of a Mediator Subunit in Caenorhabditis elegans. Genetics. 2018 July 23.

8. Wang H, Park H, Liu J, Sternberg PW.  An Efficient Genome Editing Strategy to Generate Putative Null Mutants in Caenorhabditis elegans Using CRISPR/Cas9.  G3: Genes, Genome, Genetics.  November 1, 2018 8(11):3607-3616;

9. Sternberg PW. Opening up a large can of worms. Parasite Genomics. 04 December 2018.

10. Shih PY, Lee JS, Sternberg PW. Genetic markers enable the verification and manipulation of the dauer entry decision. Dev Biol. 2019 Jun 23. pii: S0012-1606(18)30788-7. http:doi: 10.1016/j.ydbio.2019.06.009. [Epub ahead of print] PubMed PMID: 31242447.

11. Wong WR, Brugman KI, Maher S, Oh JY, Howe K, Kato M, Sternberg PW. Autism-associated missense genetic variants impact locomotion and neurodevelopment in Caenorhabditis elegans. Hum Mol Genet. 2019 Jul 1;28(13):2271-2281. doi: 10.1093/hmg/ddz051. PubMed PMID: 31220273; PubMed Central PMCID: PMC6586145.

12. Beltran T, Barroso C, Birkle TY, Stevens L, Schwartz HT, Sternberg PW, Fradin H, Gunsalus K, Piano F, Sharma G, Cerrato C, Ahringer J, Martínez-Pérez E, Blaxter M, Sarkies P. Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis. Dev Cell. 2019 Mar 25;48(6):793-810.e6. doi: 10.1016/j.devcel.2018.12.026. Epub 2019 Jan 31. PubMed PMID: 30713076; PubMed Central PMCID: PMC6436959.

New Micropublications

1. Angeles-Albores D, Lee RYN, Chan J, Sternberg PW. (2018) Two new functions in the WormBase Enrichment Suite. Micropublication: biology. Dataset.

2. Cao M, Chai C, Liu J, Sternberg PW. (2018) Application of the red-shifted channelrhodospin Chrimson for the Caenorhabdidits elegans cGAL bipartite system.  Micropublication:biology.  Dataset.

3. Cho J, Grove C, Van Auken K, Chan J, Gao S, Sternberg PW. (2018) Update on protein-protein interaction data in WormBase. Micropublication:biology. Dataset.

4. Oh JY, Gharib S, Liu J, Wang H, Sternberg PW. (2019) DVC interneuron cGAL driver in Caenorhabditis elegans. MicroPublication Biology.